Publications

Book Chapter

• O'Dowd, H.; Erwin, A. L.; Lewis J. G. Lincosamide Antibacterials, in NATURAL PRODUCTS IN MEDICINAL CHEMISTRY (ed. S. Hanessian), 2014, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. Chapter 7.

Journal Articles

• Finn P.D.; Rodriguez D.; Kohler J.; Jiang Z.; Wan S.; Blanco E.; King A. J.; Chen T.; Bell N.; Dragoli D.; Jacobs J. W.; Jain R.; Leadbetter M.; Siegel M.; Carreras C. W.; Koo-McCoy S.; Shaw K.; Le C.; Vanegas S.; Hsu I. H.; Kozuka K.; Okamoto K.; Caldwell J. S.; Lewis J. G. Intestinal TGR5 Agonism Improves Hepatic Steatosis and Insulin Sensitivity in Western Diet-fed Mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2019 March 1; 316 (3): 412-424.
• King A. J.; Siegel M.; He Y.; Nie B.; Wang J.; Koo-McCoy S.; Minassian N. A.; Jafri Q.; Pan D.; Kohler J.; Kumaraswamy P.; Kozuka K.; Lewis J. G.; Dragoli D.; Rosenbaum D. P.; O'Neill D.; Plain A.; Greasley P. J.; Jönsson-Rylander A. C.; Karlsson D.; Behrendt M.; Strömstedt M.; Ryden-Bergsten T.; Knöpfel T.; Pastor A. E. M.; Hernando N.; Marks J.; Donowitz M.; Wagner C. A.; Alexander R. T.; Caldwell J. S. Inhibition of Sodium/Hydrogen Exchanger 3 in the Gastrointestinal Tract by Tenapanor Reduces Paracellular Phosphate Permeability. Sci. Transl. Med. 2018 August 29;10 456.
• Chen T.; Reich N. W.; Bell, N.; Finn P. D.; Rodriguez D.; Kohler J.; Kozuka K.; He L.; Spencer A. G.; Charmot D. C.; Navre M.; Carreras C. W.; Koo-McCoy S.; Tabora J.; Caldwell J. S.; Jacobs J. W.; Lewis J. G.; Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5) Journal of Medicinal Chemistry 2018, 61, 17, 7589-7613.
• Kozuka K.; He Y.; Koo-McCoy S.; Kumaraswamy P.; Nie B.; Shaw K.; Chan P.; Leadbetter M.; He L.; Lewis J.G.; Zhong Z.; Charmot D.; Balaa M.; King A. J.; Caldwell J.S.; Siegel M. Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform. Stem Cell Reports. 2017 December 12; 9(6): 1976-1990.
• Labonté E.D.; Carreras C.W.; Leadbetter M.R.; Kozuka K.; Kohler J.; Koo-McCoy S.; He L.; Dy E.; Black D.; Zhong Z.; Langsetmo I.; Spencer A.G.; Bell N.; Deshpande D.; Navre M.; Lewis J.G.; Jacobs J.W.; Charmot D. Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD. J. Am. Soc. Nephrol. 2015 May; 26 (5):1138-1149.
• Wishka D. G.; Bédard M.; Brighty K. E.; Buzon R. A.; Farley K. A.; Fichtner M. W.; Kauffman G. S.; Kooistra J.; Lewis J. G.; O'Dowd H.; Samardjiev I. J.; Samas B.; Yalamanchi G.; Noe M. C. An Asymmetric Synthesis of (2S,5S)-5-Substituted Azepane-2-carboxylate Derivatives. J. Org. Chem. March 2011, 18; 76 :1937-1940
• O'Dowd H.; Lewis J. G.; Gordeev M. F. Novel 6-Position Modified 1-Thioalkyl-Lincosamines. Tetrahedron Letters. April 2008, 49, 18, 2979-2981.
• O'Dowd H.; Lewis J. G.; Trias J.; Asano R.; Blais J.; Lopez S. L.; Park C. K.; Wu C.; Wang W.; Gordeev M. F. Novel Antibacterial Azetidine Lincosamides. Bioorganic Medicinal Chemistry Letters. April 2008, 8, 2645-2648.
• Lewis, J. G.; Bartlett, P. A. Amino Acid-Derived Heterocycles as Combinatorial Library Targets: Bicyclic Aminal Lactones. Journal of Combinatorial Chemistry. 2003, 5, 278-284.
• Hackbarth, C. H.; Chen, D. Z.; Lewis, J. G.; Clark, K.; Mangold, J. B.; Cramer, J. A.; Margolis, P. S.; Wang, W.; Koehn, J.; Wu, C.; Lopez, S.; Withers, G.; Gu, H.; Dunn, E.; Kulathila, R.; Pan, S.; Porter, W. L.; Jacobs, J.; Trias, J.; Patel, D. V.; Weidmann B.; White, R. J.; Yuan, Z. N-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity. Antimicrobial Agents and Chemotherapy, September 2002, 46, 2752–2764.
• Lewis, J. G.; Lin, K. Y.; Kothavale, A.; Flanagan, W. M.; Matteucci, M. D.; Deprince, R. B.; Mook, R. A. Jr.; Hendren, R.W.; Wagner, R.W. A Serum-Resistant Cytofectin for Cellular Delivery of Antisense Oligodeoxynucleotides and Plasmid DNA. Proceedings of the National Academy of Sciences of the United States of America 1996, 93, 3176-3181.
• Moulds, C.; Lewis, J. G.; Froehler, B. C.; Grant, D.; Huang, T.; Milligan, J. F.; Matteucci, M. D.; Wagner, R. W. Site and Mechanism of Antisense Inhibition by C-5 Propyne Oligonucleotides. Biochemistry 1995, 34, 5044-5053.
• Wagner, R. W.; Matteucci, M. D.; Lewis, J. G.; Gutierrez, A. J.; Moulds, C.; Froeler, B. D. Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines. Science 1993, 260, 1510-1513.